SnapShot: Endogenous RNAi Pathways

SnapShot: Endogenous RNAi Pathways

Due to an error in the proofing process, the word ''RNAi'' was originally set as ''RNA'' in the title of the above SnapShot. The title has been corrected online.

SnapShot: Endogenous RNAi Machinery and Mechanisms

See online version for legend and references.

Endogenous RNAi pathways in C. elegans.

In addition to several hundred microRNAs, C. elegans produces thousands of other small RNAs targeting coding genes, pseudogenes, transposons, and other noncoding RNAs. Here we review what is currently known about these endogenous small interfering RNAs (siRNAs) and piwi-interacting RNAs (piRNAs), providing an overview of their biogenesis, their associated protein factors, and their effects on m...

Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans.

C. elegans contains numerous small RNAs of ~21-24 nt in length. The microRNAs (miRNAs) are small noncoding RNAs produced by DCR-1- and ALG-dependent processing of self-complementary hairpin transcripts. Endogenous small interfering RNAs (endo-siRNAs), associated with ongoing silencing of protein-coding genes in normal worms, are produced by mechanisms that involve DCR-1 but, unlike miRNAs, also...

SnapShot: Extrinsic Apoptosis Pathways